Meczekalski B
Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Poznan, Poland.
J Endocrinol Invest. 2009 May;32(5):474-81. doi: 10.1007/BF03346489.
Genetic determinations of oocyte and ovarian follicle growth are still not well understood. Genes specifically expressed on oocytes seem to play an important role in these processes. Oocyte-specific genes are also involved in ovulation and early embryogenesis processes. Studies on the identification and characterization of new oocyte-specific genes can help in our understanding of cardinal fertility and infertility mechanisms. They can also be candidate genes for reproductive disorders such as polycystic ovary syndrome, premature ovarian failure and infertility. Infertility is an important worldwide problem affecting around 15% of couples. Approximately 20% of infertility is referred as idiopathic infertility. Studies on these genes could improve the diagnostic and therapeutic procedures of human infertility.
卵母细胞和卵泡生长的遗传决定因素仍未得到充分理解。在卵母细胞上特异性表达的基因似乎在这些过程中发挥重要作用。卵母细胞特异性基因也参与排卵和早期胚胎发育过程。对新的卵母细胞特异性基因的鉴定和表征研究有助于我们理解主要的生育和不孕机制。它们也可能是诸如多囊卵巢综合征、卵巢早衰和不孕等生殖障碍的候选基因。不孕是一个影响全球约15%夫妇的重要问题。大约20%的不孕被称为特发性不孕。对这些基因的研究可以改善人类不孕的诊断和治疗程序。
