Lisander B, Jaju B, Wang S C
Eur J Pharmacol. 1975 Mar;31(1):53-62. doi: 10.1016/0014-2999(75)90078-3.
Diphenylhydantoin (DPH) is known to be a potent anticonvulsant agent, useful in treating and preventing grand mal seizures. More recently, DPH was reported also to be a potent antiarrhythmic agent acting by means of a depressant action on the heart. The present experiments demonstrated that DPH has also a potent antiarrhythmic action when administered to the CNS. The posterolateral hypothalamus was stimulated in cats to evoke cardiac arrhythmias of varying severity both during and after stimulation. In general, it was found that the post-stimulus arrhythmias were obtained more readily than those during stimulation. The mean effective dose of DPH required to prevent the arrhythmias via the i.v. route was 11.9 mg/kg, and that via the vertebral artery route and via the fourth ventricular route was only 1.9--1.4 and 1.4 mg/kg, respectively. These results suggest that though DPH has identifiable antiarrhythmic action on the heart itself it has a strong antiarrhythmic effect via the central nervous system as well.
苯妥英（DPH）是一种有效的抗惊厥药物，可用于治疗和预防癫痫大发作。最近，有报道称DPH也是一种有效的抗心律失常药物，通过对心脏的抑制作用发挥作用。目前的实验表明，当将DPH施用于中枢神经系统时，它也具有强大的抗心律失常作用。对猫的下丘脑后外侧进行刺激，以在刺激期间和刺激后诱发不同严重程度的心律失常。一般来说，发现刺激后心律失常比刺激期间更容易诱发。通过静脉途径预防心律失常所需的DPH平均有效剂量为11.9mg/kg，通过椎动脉途径和第四脑室途径分别仅为1.9 - 1.4mg/kg和1.4mg/kg。这些结果表明，尽管DPH对心脏本身具有可识别的抗心律失常作用，但它通过中枢神经系统也具有很强的抗心律失常作用。
