二苯乙内酰脲和钾对豚鼠心脏中哇巴因生物活性的影响。
The effects of diphenylhydantoin and potassium on the biological activity of ouabain in the guinea-pig heart.
作者信息
Baskin S I, Dutta S, Marks B H
出版信息
Br J Pharmacol. 1973 Jan;47(1):85-96. doi: 10.1111/j.1476-5381.1973.tb08161.x.
Abstract
- Diphenylhydantoin (DPH) and potassium significantly prevent ouabain intoxication without preventing the inotropic effects of ouabain in the guinea-pig isolated heart.2. The antiarrhythmic effect of DPH and K on ouabain-induced toxicity appears to be related to their ability to reduce ouabain accumulation by the myocardium and thereby prevent the intracellular Na and K changes which lead to the arrhythmic state.
摘要
- 苯妥英钠（DPH）和钾可显著预防哇巴因中毒，同时又不会阻止哇巴因对豚鼠离体心脏的变力作用。2. DPH和钾对哇巴因诱导的毒性的抗心律失常作用，似乎与其降低心肌对哇巴因的蓄积能力有关，从而防止导致心律失常状态的细胞内钠和钾的变化。
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