Horner P, Thomas B, Gilroy C B, Egger M, Taylor-Robinson D
Genitourinary Medicine Section, Department of Medicine, Imperial College of Medicine, St. Mary's Hospital, Paddington, London, United Kingdom.
Clin Infect Dis. 2001 Apr 1;32(7):995-1003. doi: 10.1086/319594. Epub 2001 Mar 15.
One hundred fourteen heterosexual men with acute nongonococcal urethritis (NGU) and 64 patients without NGU were studied. We determined that Chlamydia trachomatis and Mycoplasma genitalium were strongly associated with acute NGU after controlling, by means of multivariate analysis, for age, race, sexual lifestyle, and coinfection (odds ratio [OR], 13.0, 95% confidence interval [CI], 2.6-64.5; and OR, 17.9, 95% CI, 2.0-160, respectively). Eighty-six men with acute NGU reattended at least once 10-92 days after treatment; 59 (69%) of these 86 men had urethritis. Seven men had M. genitalium detected during 10-92 days of follow-up, and all had urethritis. Ureaplasmas were not associated with acute NGU in multivariate analysis, but their detection was associated with the presence of urethritis during follow-up (P=.014). Ureaplasmas or M. genitalium were associated with both chronic NGU, which was defined as urethritis that occurred 30-92 days after the commencement of treatment (P=.028), and chronic NGU with symptoms or signs (P=.005).
对114名患有急性非淋菌性尿道炎（NGU）的异性恋男性和64名未患NGU的患者进行了研究。通过多变量分析控制年龄、种族、性生活方式和合并感染后，我们确定沙眼衣原体和生殖支原体与急性NGU密切相关（优势比[OR]分别为13.0，95%置信区间[CI]为2.6 - 64.5；以及OR为17.9，95%CI为2.0 - 160）。86名患有急性NGU的男性在治疗后10 - 92天至少复诊过一次；这86名男性中有59名（69%）患有尿道炎。7名男性在随访的10 - 92天内检测出生殖支原体，且均患有尿道炎。在多变量分析中，脲原体与急性NGU无关，但其检测结果与随访期间尿道炎的存在相关（P = 0.014）。脲原体或生殖支原体与慢性NGU均相关，慢性NGU定义为治疗开始后30 - 92天出现的尿道炎（P = 0.028），以及伴有症状或体征的慢性NGU（P = 0.005）。
