大鼠细小病毒在胸腺淋巴瘤细胞系C58(NT)d中的增殖以及溶细胞感染后抗性细胞克隆的出现。
Propagation of rat parvovirus in thymic lymphoma cell line C58(NT)d and subsequent appearance of a resistant cell clone after lytic infection.
作者信息
Ueno Y, Harada T, Iseki H, Ohshima T, Sugiyama F, Yagami K
机构信息
Institute of Basic Medical Sciences and Laboratory Animal Research Center, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
出版信息
J Virol. 2001 Apr;75(8):3965-70. doi: 10.1128/JVI.75.8.3965-3970.2001.
Abstract
Rat parvovirus (RPV) is nonpathogenic in rats but causes persistent lymphocytotropic infection. We found that RPV was propagated in rat thymic lymphoma cell line C58(NT)D and induced apoptosis. Interestingly, a resistant subclone, C58(NT)D/R, from surviving cells after lytic infection had differentiated phenotypic modifications, such as increased cell adherence, resistance to apoptosis, and suppressed tumorigenicity.
摘要
大鼠细小病毒（RPV）对大鼠无致病性，但会引起持续性嗜淋巴细胞感染。我们发现RPV可在大鼠胸腺淋巴瘤细胞系C58(NT)D中增殖并诱导细胞凋亡。有趣的是，来自溶细胞感染后存活细胞的抗性亚克隆C58(NT)D/R具有分化的表型修饰，如细胞黏附增加、抗凋亡能力增强以及致瘤性受到抑制。
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