Dammann O, Hagberg H, Leviton A
Neuroepidemiology Unit, Department of Neurology, Children's Hospital, Boston, Massachusetts 02115, U.S.A.
Pediatr Res. 2001 Apr;49(4):453-7. doi: 10.1203/00006450-200104000-00003.
Periventricular leukomalacia is a white matter disorder, the neonatal cranial ultrasound images of which predict long-term developmental limitations among preterm infants. The vulnerability of oligodendrocytes has led to the hypothesis that oligodendrocytes suffer the primary damage, with axonal damage occurring as a consequence. In this article, we discuss the differential role of oligodendrocytes and axons in this disorder's etiology, offering analogies from the multiple sclerosis and hydrocephalus literature. We conclude that it is too early to view periventricular leukomalacia exclusively as a consequence of oligodendrocyte damage and/or maldevelopment.
脑室周围白质软化是一种白质疾病，其新生儿颅脑超声图像可预测早产儿的长期发育受限情况。少突胶质细胞的脆弱性导致了这样一种假说，即少突胶质细胞遭受原发性损伤，轴突损伤随之发生。在本文中，我们讨论了少突胶质细胞和轴突在这种疾病病因中的不同作用，并借鉴了多发性硬化症和脑积水文献中的相关内容。我们的结论是，将脑室周围白质软化完全视为少突胶质细胞损伤和/或发育异常的结果，目前还为时过早。
