Diaz-Infante A, Wright K H, Wallach E E
Fertil Steril. 1975 Feb;26(2):101-10.
Five female rhesus monkeys were treated with natural estrogens, 5 mg/day for three weeks, after which ovarian contractility was studied in vitro in one of the ovaries. Estrogen treatment was followed by progesterone, 25 mg/day for three weeks, after which the contractility of the remaining ovary was similarly measured. Responses to autonomic agents and prostaglandins were studied in both groups. Spontaneous ovarian contractility and ovarian contractile responsiveness to prostaglandins and norepinephrine were found to be enhanced after progesterone treatment. Cholinergic agonists had a stimulatory effect after progesterone and an inhibitory effect after estrogens. Our results suggest that ovarian contractile responsiveness is modified by the local steroid environment, perhaps through intracellular changes in cyclic AMP.
五只雌性恒河猴接受天然雌激素治疗，每天5毫克，持续三周，之后对其中一侧卵巢进行体外卵巢收缩性研究。雌激素治疗后给予孕酮，每天25毫克，持续三周，之后对另一侧卵巢的收缩性进行同样测量。对两组均研究了对自主神经药物和前列腺素的反应。发现孕酮治疗后自发性卵巢收缩性以及卵巢对前列腺素和去甲肾上腺素的收缩反应性增强。胆碱能激动剂在孕酮作用后有刺激作用，在雌激素作用后有抑制作用。我们的结果表明，卵巢收缩反应性可能通过环磷酸腺苷的细胞内变化而受到局部类固醇环境的影响。
