Sonneveld P, Peperkamp E, van Bekkum D W
Radiology. 1979 Oct;133(1):227-9. doi: 10.1148/133.1.227.
The incidence of cataract formation was investigated in rhesus monkeys exposed to different doses of whole-body irradiation. Application of 850-900 rad (8.5-9 Gy) caused cataracts in 17% of the monkeys within 3 years after treatment; after 10 to 15 years, incidence increased to 100%. "Young" lenses showed a significantly lower incidence than "adult" lenses, although no differences in the stage of cataractogenesis could be demonstrated. Sex differences did not play a role in incidence and severity of cataracts. Lower doses (400 rad or 4 Gy) did not cause cataracts. In view of the close similarity between monkeys and humans, these results indicate that a single dose of 850-900 rad, sometimes employed in the treatment of acute myeloid leukemia in children, carries a strong risk of cataract development.
研究了接受不同剂量全身照射的恒河猴白内障形成的发生率。给予850 - 900拉德（8.5 - 9戈瑞）照射后，17%的猴子在治疗后3年内出现白内障；10至15年后，发生率增至100%。“年轻”晶状体的发生率显著低于“成年”晶状体，尽管在白内障发生阶段未发现差异。性别差异在白内障的发生率和严重程度方面不起作用。较低剂量（400拉德或4戈瑞）未导致白内障。鉴于猴子与人类极为相似，这些结果表明，有时用于治疗儿童急性髓系白血病的单次850 - 900拉德照射，具有很高的白内障发生风险。
