Anant S, Davidson N O
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Curr Opin Lipidol. 2001 Apr;12(2):159-65. doi: 10.1097/00041433-200104000-00009.
A site-specific post-transcriptional cytidine to uridine deamination reaction is responsible for the production of apolipoprotein B48 in the mammalian small intestine. The molecular machinery responsible for apolipoprotein B RNA editing consists of apobec-1, an RNA-specific cytidine deaminase that functions in conjunction with a recently identified protein referred to as ACF/ASP. These proteins together represent the minimal editing enzyme, although other proteins may associate with the enzyme complex. Apobec-1 is a member of a supergene family of cytidine deaminases, with several homologs recently identified in the human genome. ACF/ASP is novel, and emerging information reveals interesting clues to its role in the apolipoprotein B RNA editing enzyme complex.
一种位点特异性的转录后胞苷到尿苷脱氨反应负责在哺乳动物小肠中产生载脂蛋白B48。负责载脂蛋白B RNA编辑的分子机制由载脂蛋白B编辑催化蛋白1（apobec-1）组成，它是一种RNA特异性胞苷脱氨酶，与最近鉴定出的一种称为ACF/ASP的蛋白质协同发挥作用。这些蛋白质共同构成了最小的编辑酶，尽管其他蛋白质可能与该酶复合物相关联。载脂蛋白B编辑催化蛋白1是胞苷脱氨酶超基因家族的成员，最近在人类基因组中鉴定出了几个同源物。ACF/ASP是新发现的，新出现的信息揭示了其在载脂蛋白B RNA编辑酶复合物中的作用的有趣线索。
