Vega I, León A, Zolezzi P, Ibarra H, Faúndez C, Montecinos J
Institutos de Hematología y Medicina, Facultad de Medicina, Universidad Austral de Chile, Valdivia.
Rev Med Chil. 2001 Jan;129(1):18-22.
Little information is available in Chile about hepatitis C virus (HCV) in hematological and oncohematological patients.
To evaluate the prevalence of hepatitis C virus markers in a group of hematological and oncohematological pediatric patients seen at Valdivia Regional Hospital.
Antibodies against virus C, determined by ELISA and viral RNA, determined using RT-polymerase chain reaction, were measured in 54 blood samples from children with hematological diseases (34 with Acute Lymphoblastic Leukaemia, 4 with Hodgkin Diseases, 4 with Haemolytic Anemia, 5 with Sarcomas, 2 with Non-Hodgkin Lymphoma, 2 with Thrombocytopenic Purpura, 1 with an Ependimoma, one with a Wilms Tumor and 1 with a Von Willebrand Disease).
All samples were negative for antibodies against hepatitis C virus. Viral RNA was found in four children, all with a diagnosis of acute lymphoblastic leukemia and who received chemotherapy and multiple transfusions.
The prevalence of Viral RNA for hepatitis C virus in oncohematological patients in our study is high and associated with the use of chemotherapy and multiple transfusions.
在智利，关于血液学和肿瘤血液学患者中的丙型肝炎病毒（HCV）的信息很少。
评估在瓦尔迪维亚地区医院就诊的一组血液学和肿瘤血液学儿科患者中丙型肝炎病毒标志物的患病率。
采用酶联免疫吸附测定法（ELISA）测定针对病毒C的抗体，并使用逆转录聚合酶链反应（RT-PCR）测定病毒RNA，对54例血液系统疾病患儿的血样进行检测（34例急性淋巴细胞白血病、4例霍奇金病、4例溶血性贫血、5例肉瘤、2例非霍奇金淋巴瘤、2例血小板减少性紫癜、1例室管膜瘤、1例肾母细胞瘤和1例血管性血友病）。
所有样本的丙型肝炎病毒抗体均为阴性。在4名儿童中发现了病毒RNA，所有患儿均诊断为急性淋巴细胞白血病，且接受了化疗和多次输血。
在我们的研究中，肿瘤血液学患者中丙型肝炎病毒的病毒RNA患病率很高，且与化疗和多次输血有关。
