全反式维甲酸联合小剂量阿糖胞苷治疗伴三系骨髓发育异常的急性髓系白血病——病例报告
[All-trans retinoic acid combined with low-dose cytosine arabinoside treatment for acute myelogenous leukemia with trilineage myelodysplasia--a case report].
作者信息
Maeda N, Satake S, Okada Y, Asahara S, Hasuike N, Tamura M, Takata M, Tasaka K, Okutani T, Maeda Y, Tomofuji Y, Chinzei T, Saigo K
机构信息
Dept. of Internal Medicine, Kakogawa Municipal Hospital.
出版信息
Gan To Kagaku Ryoho. 2001 Mar;28(3):407-10.
AML with trilineage myelodysplasia (AML/TMDS) is recognized as having of poor prognosis due to its resistance to chemotherapy in comparison with de novo AML. An AML/TMDS patient who failed to respond to ordinary induction therapy achieved complete remission with combination therapy consisting of all-trans retinoic acid (ATRA) and low-dose Ara-C. No serious toxicity was observed. ATRA combined with low-dose Ara-C could be an alternative treatment for this kind of patient.
伴有三系骨髓发育异常的急性髓系白血病（AML/TMDS）被认为预后较差，因为与原发性AML相比，它对化疗具有耐药性。一名对普通诱导治疗无反应的AML/TMDS患者通过全反式维甲酸（ATRA）和小剂量阿糖胞苷的联合治疗实现了完全缓解。未观察到严重毒性。ATRA联合小剂量阿糖胞苷可能是这类患者的一种替代治疗方法。
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