奈必洛尔在基于直链淀粉的正相和反相手性固定相上的高效液相色谱对映体拆分
HPLC enantiomeric resolution of nebivolol on normal and reversed amylose based chiral phases.
作者信息
Aboul-Enein H Y, Ali I
机构信息
Pharmaceutical Analysis Laboratory, Biological and Medical Research Department (MBC-03), King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
出版信息
Pharmazie. 2001 Mar;56(3):214-6.
Racemic nebivolol, a beta-adrenergic blocker showing very promising beta-adrenergic antagonist properties in comparison to other beta-adrenergic blockers has been resolved by HPLC under normal and reversed phase modes. The columns used were Chiralpak AD and Chiralpak AD-RH containing amylose tris (3,5-dimethyl phenyl carbamate) as the chiral selector. The mobile phases used were pure ethanol and 1-propanol. The flow rates used were 0.5, 1.0 and 1.5 ml/min. The best resolution was achieved at 0.5 ml/min. flow rate with ethanol and 1-propanol on both Chiralpak AD and Chiralpak AD-RH stationary phases. The values of infinity for both alcohols on Chiralpak AD were 1.38 while on Chiralpak AD-RH these values were 1.41 and 1.38 respectively. The values of Rs for ethanol and 1-propanol were 2.63 and 1.71 on Chiralpak AD and 1.73 and 1.76 on Chiralpak AD-RH respectively.
消旋奈必洛尔是一种β-肾上腺素能阻滞剂，与其他β-肾上腺素能阻滞剂相比，具有非常有前景的β-肾上腺素能拮抗剂特性。它已通过高效液相色谱法在正相和反相模式下拆分。所使用的色谱柱是Chiralpak AD和Chiralpak AD-RH，它们含有直链淀粉三（3,5-二甲基苯基氨基甲酸酯）作为手性选择剂。所使用的流动相是纯乙醇和1-丙醇。所使用的流速为0.5、1.0和1.5毫升/分钟。在流速为0.5毫升/分钟时，使用乙醇和1-丙醇在Chiralpak AD和Chiralpak AD-RH固定相上均实现了最佳拆分。在Chiralpak AD上两种醇的无穷大值均为1.38，而在Chiralpak AD-RH上这些值分别为1.41和1.38。在Chiralpak AD上乙醇和1-丙醇的分离度值分别为2.63和1.71，在Chiralpak AD-RH上分别为1.73和1.76。
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