用于癌症诊疗的聚合物纳米药物研究进展

Progress in Polymeric Nano-Medicines for Theranostic Cancer Treatment.

作者信息

Ali Imran, Alsehli Mosa, Scotti Luciana, Tullius Scotti Marcus, Tsai Shang-Ting, Yu Ruei-Siang, Hsieh Ming Fa, Chen Jung-Chih

机构信息

Department of Chemistry, College of Sciences, Taibah University, Al-Medina Al-Munawara 41477, Saudi Arabia.

Department of Chemistry, Jamia Millia Islamia (Central University), New Delhi 110025, India.

出版信息

Polymers (Basel). 2020 Mar 6;12(3):598. doi: 10.3390/polym12030598.

DOI:10.3390/polym12030598

PMID:32155695

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7182942/

Abstract

Cancer is a life-threatening disease killing millions of people globally. Among various medical treatments, nano-medicines are gaining importance continuously. Many nanocarriers have been developed for treatment, but polymerically-based ones are acquiring importance due to their targeting capabilities, biodegradability, biocompatibility, capacity for drug loading and long blood circulation time. The present article describes progress in polymeric nano-medicines for theranostic cancer treatment, which includes cancer diagnosis and treatment in a single dosage form. The article covers the applications of natural and synthetic polymers in cancer diagnosis and treatment. Efforts were also made to discuss the merits and demerits of such polymers; the status of approved nano-medicines; and future perspectives.

摘要

癌症是一种危及生命的疾病，在全球导致数百万人死亡。在各种医学治疗方法中，纳米药物的重要性不断增加。已经开发了许多用于治疗的纳米载体，但基于聚合物的纳米载体因其靶向能力、生物可降解性、生物相容性、药物负载能力和长血液循环时间而变得越来越重要。本文描述了用于癌症治疗诊断的聚合物纳米药物的进展，其中包括以单一剂型进行癌症诊断和治疗。文章涵盖了天然和合成聚合物在癌症诊断和治疗中的应用。还努力讨论了此类聚合物的优缺点、已批准纳米药物的现状以及未来展望。