Ingkatawornwong S, Kaewnopparat N, Tantishaiyakul V
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, Thailand.
Pharmazie. 2001 Mar;56(3):227-30.
The stabilities of X-ray amorphous solid dispersions of piroxicam and polyvinylpyrrolidone (PVP) K-17 and PVP K-30 (1:5 and 1:4), respectively, were investigated after storage for 12 months. X-ray diffraction showed that in the aged solid dispersions piroxicam remained in the amorphous state. Fourier transform infrared (FTIR) spectroscopy indicated that the interactions between drug and PVP in aged solid dispersions are similar to those in freshly prepared samples. The dissolution rates of the X-ray amorphous solid dispersions during storage for 12 months at 45 degrees C and ambient temperature were examined. Very minor decreases in dissolution rates of aged solid dispersions were found which might be due to the coarsening of the particles. Dissolutions of these amorphous solid dispersions after aging for 12 months still showed an about 40-fold increase in dissolution in 5 min compared to pure drug.
分别研究了吡罗昔康与聚乙烯吡咯烷酮（PVP）K-17和PVP K-30（比例分别为1:5和1:4）形成的X射线非晶态固体分散体在储存12个月后的稳定性。X射线衍射表明，在老化的固体分散体中，吡罗昔康仍处于非晶态。傅里叶变换红外（FTIR）光谱表明，老化固体分散体中药物与PVP之间的相互作用与新鲜制备样品中的相似。考察了X射线非晶态固体分散体在45℃和室温下储存12个月期间的溶出速率。发现老化固体分散体的溶出速率有非常轻微的下降，这可能是由于颗粒粗化所致。这些非晶态固体分散体老化12个月后的溶出度与纯药物相比，在5分钟内仍显示出约40倍的增加。
