James A E, Montali R J, Chaffee V, Strecker E P, Vessal K
Gastroenterology. 1975 May;68(5 Pt 1):1103-13.
In order to study the effects of the commonly employed contrast media alone and in combination with bacteria in the mediastinum, various mixtures of barium and meglamine diatrizoate (Gastrografin) with and without flora were instilled in the mediastinum of 29 domestic cats. The animals were killed for pathological studies at serial time intervals following mediastina injection. These data demonstrate that water-soluble contrast media cause no significant histological reaction. Barium causes granuloma formation but has no additional deleterious effects when mixed with flora. Barium has superior physical properties of mucosal coating and radiographic density. It should be employed as the contrast agent of choice in difficult clinical problems with regard to esophageal tears. A water-soluble contrast study of the esophagus may be utilized as the initial diagnostic procedure, but if this is normal a follow-up barium esophagram is recommended.
为了研究常用造影剂单独以及与细菌联合在纵隔中的作用，将含有和不含有菌群的钡剂与泛影葡胺（ Gastrografin ）的各种混合物注入29只家猫的纵隔。在纵隔注射后的连续时间间隔处死动物进行病理学研究。这些数据表明，水溶性造影剂不会引起明显的组织学反应。钡剂会导致肉芽肿形成，但与菌群混合时没有额外的有害影响。钡剂在黏膜涂层和放射密度方面具有优越的物理特性。在食管撕裂的疑难临床问题中，应将其作为首选造影剂。食管的水溶性造影检查可作为初始诊断程序，但如果结果正常，建议进行后续的食管钡餐造影。
