Spatt J, Chaix R, Mamoli B
Neurologische Abteilung Neurologisches Krankenhaus Rosenhügel Ludwig Boltzmann Institut für Epilepsie und Neuromuskuläre Erkrankungen, Vienna, Austria.
J Neurol. 2001 Jan;248(1):2-9. doi: 10.1007/s004150170262.
Knowledge concerning the relationship between multiple sclerosis and epilepsy is reviewed. Epidemiological studies have established that epileptic seizures are more frequent in multiple sclerosis than predicted by chance. Partial epilepsies with focal seizures often with atypical symptoms and with or without secondary generalisation are the usual pattern. In the survey special emphasis is laid on the direct correlation between paroxysmal phenomena and plaques now demonstrable by modern imaging techniques. These images have shown that epileptic seizures can be caused by cortical and subcortical lesions and by their accompanying oedema. We extend the review to non-epileptic paroxysmal symptoms, such as tonic spasm, which may be confused with epileptic seizures. As far as they are supported by data, recommendations for diagnosis and therapy are given. Open questions are identified and issues for further research are suggested.
本文综述了关于多发性硬化症与癫痫之间关系的知识。流行病学研究表明，癫痫发作在多发性硬化症患者中比偶然预期的更为频繁。以局灶性发作为特征的部分性癫痫，常伴有非典型症状，有或无继发性全身性发作，是常见模式。在本次综述中，特别强调现代成像技术现已证实的发作性现象与斑块之间的直接关联。这些影像显示，癫痫发作可能由皮质和皮质下病变及其伴随的水肿引起。我们将综述范围扩展至非癫痫性发作症状，如可能与癫痫发作相混淆的强直性痉挛。在有数据支持的情况下，给出了诊断和治疗建议。明确了未解决的问题，并提出了进一步研究的方向。
