Zare Mohammad, Norouzi Rasul, Shayegannejad Vahid, Ashtari Fereshteh, Ghasemi Majid, Tavahen Hemaseh, Masaeli Ali
Department of Neurology, Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2013 Jul;18(7):558-60.
There is a broad variation in reported frequencies of seizure in multiple sclerosis (MS). In this study, the seizure and its characteristics analyzed among a large group of patients with MS.
We reviewed the medical records of all definite MS patients referred to the MS Clinic of Kashani hospital, Isfahan, Iran, between 2007 and 2011.
Altogether, 34 cases with seizure activity identified among the 920 definite MS subjects (3.69%). Five excluded due to the other probable etiologies rather than MS. In the remained 29 patients (3.15%), the type of seizure was mostly generalized (79.3%); interictal electroencephalography showed an abnormal pattern in 84.6%, brain magnetic resonance imaging revealed subcortical white mater lesions in 84.6% of patients. The mean duration of MS onsets was 8.17 years and the mean interval between MS onset and the first seizure occurrence was 3.7 years. In general, response to antiepileptic treatment was excellent.
Seizures can occur at any stage during the course of MS, but it is more common during the early stages.
多发性硬化症（MS）患者癫痫发作的报告频率存在很大差异。在本研究中，对一大群MS患者的癫痫发作及其特征进行了分析。
我们回顾了2007年至2011年间转诊至伊朗伊斯法罕卡沙尼医院MS诊所的所有确诊MS患者的病历。
在920名确诊的MS患者中，共识别出34例有癫痫发作活动（3.69%）。5例因其他可能病因而非MS被排除。在其余29例患者（3.15%）中，癫痫发作类型大多为全身性（79.3%）；发作间期脑电图显示84.6%有异常模式，脑磁共振成像显示84.6%的患者有皮质下白质病变。MS发病的平均持续时间为8.17年，MS发病与首次癫痫发作之间的平均间隔为3.7年。总体而言，对抗癫痫治疗的反应良好。
癫痫发作可发生在MS病程的任何阶段，但在早期更为常见。
