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黑人高血压:与基于种族的研究相比,对特定基因型和表型的研究将更有助于深入了解个体间和种族间血压调节的变异性。

Hypertension in black people: study of specific genotypes and phenotypes will provide a greater understanding of interindividual and interethnic variability in blood pressure regulation than studies based on race.

作者信息

Stein C M, Lang C C, Xie H G, Wood A J

机构信息

Division of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232-6602, USA.

出版信息

Pharmacogenetics. 2001 Mar;11(2):95-110. doi: 10.1097/00008571-200103000-00001.

Abstract

Hypertension is more frequent and more severe in some Black populations. Although many studies have focused on hypertension in black people in an attempt to understand the genetic and environmental factors that regulate blood pressure, this approach has not been productive. Study of the relationship between specific phenotypes and genotypes, both within and across ethnic groups, is more likely to advance our understanding of the regulation of blood pressure than studies focused on race and blood pressure.

摘要

高血压在一些黑人人群中更为常见且更为严重。尽管许多研究聚焦于黑人的高血压,试图了解调节血压的遗传和环境因素,但这种方法并未取得成效。研究特定表型与基因型之间在种族内部和种族之间的关系,比专注于种族与血压的研究更有可能增进我们对血压调节的理解。

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