血清素转运体启动子多态性（5HTTLPR）双等位基因和三等位基因基因型与血压及高血压患病率关联的人群差异。
Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence.
作者信息
Williams Redford B, Bishop George D, Haberstick Brett C, Smolen Andrew, Brummett Beverly H, Siegler Ilene C, Babyak Michael A, Zhang Xiaodong, Tai E Shyong, Lee Jeannette Jen-Mai, Tan Maudrene, Teo Yik Ying, Cai Shiwei, Chan Edmund, Halpern Carolyn Tucker, Whitsel Eric A, Bauldry Shawn, Harris Kathleen Mullan
机构信息
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
Yale-NUS College, Singapore, Singapore; Department of Psychology, National University of Singapore, Singapore.
出版信息
Am Heart J. 2017 Mar;185:110-122. doi: 10.1016/j.ahj.2016.12.013. Epub 2016 Dec 29.
UNLABELLED
Based on prior research finding the 5HTTLPR L allele associated with increased cardiovascular reactivity to laboratory stressors and increased risk of myocardial infarction, we hypothesized that the 5HTTLPR L allele will be associated with increased blood pressure (BP) and increased hypertension prevalence in 2 large nationally representative samples in the United States and Singapore.
METHODS
Logistic regression and linear models tested associations between triallelic (L'S', based on rs25531) 5HTTLPR genotypes and hypertension severity and mean systolic and diastolic blood pressure (SBP and DBP) collected during the Wave IV survey of the National Longitudinal Study of Adolescent to Adult Health (Add Health, N=11,815) in 2008-09 and during 2004-07 in 4196 Singaporeans.
RESULTS
In US Whites, L' allele carriers had higher SBP (0.9 mm Hg, 95% CI=0.26-1.56) and greater odds (OR=1.23, 95% CI=1.10-1.38) of more severe hypertension than those with S'S' genotypes. In African Americans, L' carriers had lower mean SBP (-1.27mm Hg, 95% CI=-2.53 to -0.01) and lower odds (OR = 0.78, 95% CI=0.65-0.94) of more severe hypertension than those with the S'S' genotype. In African Americans, those with L'L' genotypes had lower DBP (-1.13mm Hg, 95% CI=-2.09 to -0.16) than S' carriers. In Native Americans, L' carriers had lower SBP (-6.05mm Hg, 95% CI=-9.59 to -2.51) and lower odds of hypertension (OR = 0.34, 95% CI=0.13-0.89) than those with the S'S' genotype. In Asian/Pacific Islanders those carrying the L' allele had lower DBP (-1.77mm Hg, 95% CI=-3.16 to -0.38) and lower odds of hypertension (OR = 0.68, 95% CI=0.48-0.96) than those with S'S'. In the Singapore sample S' carriers had higher SBP (3.02mm Hg, 95% CI=0.54-5.51) and DBP (1.90mm Hg, 95% CI=0.49-3.31) than those with the L'L' genotype.
CONCLUSIONS
These findings suggest that Whites carrying the L' allele, African Americans and Native Americans with the S'S' genotype, and Asians carrying the S' allele will be found to be at higher risk of developing cardiovascular disease and may benefit from preventive measures.
未标注
基于先前的研究发现5HTTLPR L等位基因与对实验室应激源的心血管反应性增加以及心肌梗死风险增加相关，我们假设在美国和新加坡的两个具有全国代表性的大样本中，5HTTLPR L等位基因将与血压升高和高血压患病率增加相关。
方法
采用逻辑回归和线性模型，在2008 - 2009年全国青少年健康纵向研究（Add Health，N = 11,815）的第四次调查以及2004 - 2007年对4196名新加坡人的调查中，检验三等位基因（基于rs25531的L'S'）5HTTLPR基因型与高血压严重程度以及平均收缩压和舒张压（SBP和DBP）之间的关联。
结果
在美国白人中，L'等位基因携带者比S'S'基因型携带者的收缩压更高（0.9毫米汞柱，95%置信区间 = 0.26 - 1.56），患更严重高血压的几率更高（OR = 1.23，95%置信区间 = 1.10 - 1.38）。在非裔美国人中，L'携带者比S'S'基因型携带者的平均收缩压更低（-1.27毫米汞柱，95%置信区间 = -2.53至 -0.01），患更严重高血压的几率更低（OR = 0.78，95%置信区间 = 0.65 - 0.94）。在非裔美国人中，L'L'基因型者的舒张压比S'携带者更低（-1.13毫米汞柱，95%置信区间 = -2.09至 -0.16）。在美洲原住民中，L'携带者比S'S'基因型携带者的收缩压更低（-6.05毫米汞柱，95%置信区间 = -9.59至 -2.51），患高血压的几率更低（OR = 0.34，95%置信区间 = 0.13 - 0.89）。在亚裔/太平洋岛民中，携带L'等位基因者的舒张压比S'S'者更低（-1.77毫米汞柱，95%置信区间 = -3.16至 -0.38），患高血压的几率更低（OR = 0.68，95%置信区间 = 0.48 - 0.96）。在新加坡样本中，S'携带者比L'L'基因型者的收缩压更高（3.02毫米汞柱，9%置信区间 = 0.54 - 5.51），舒张压更高（1.90毫米汞柱，95%置信区间 = 0.49 - 3.31）。
结论
这些发现表明，携带L'等位基因的白人、具有S'S'基因型的非裔美国人和美洲原住民以及携带S'等位基因的亚洲人患心血管疾病的风险更高，可能会从预防措施中受益。
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