小鼠刺鼠基因座基因在器官培养中的表达。
Expression in organ culture of agouti locus genes of the mouse.
作者信息
Knisely A S, Gasser D L, Silvers W K
出版信息
Genetics. 1975 Mar;79(3):471-5. doi: 10.1093/genetics/79.3.471.
CLEFFMANN (1963) reported that pigment cells of the lethal yellow (A-y/a) genotype change to black immediately upon cultivation, and continue to produce black pigment unless sulfhydryl reagents are added to the culture medium. We have attempted to repeat this observation and have not been able to do so. We also have been unable to indue the synthesis of yellow pigment by adding glutathione to cultures of agouti (A/A) skin. We therefore suggest that hypotheses which attempt to explain the action of agouti locus genes on the basis of effects of sulfhydryl compounds be considered with caution.
克莱夫曼（1963年）报告称，致死黄色（A-y/a）基因型的色素细胞在培养时会立即变为黑色，并且除非在培养基中添加巯基试剂，否则会继续产生黑色色素。我们试图重复这一观察结果，但未能成功。我们也无法通过向刺鼠（A/A）皮肤培养物中添加谷胱甘肽来诱导黄色色素的合成。因此，我们建议在考虑试图基于巯基化合物的作用来解释刺鼠基因座基因作用的假说时应谨慎。
Zotero 插件