韩国幽门螺杆菌分离株对甲硝唑、克拉霉素和四环素的耐药性分析。

Analysis of metronidazole, clarithromycin and tetracycline resistance of Helicobacter pylori isolates from Korea.

作者信息

Kim J J, Reddy R, Lee M, Kim J G, El-Zaatari F A, Osato M S, Graham D Y, Kwon D H

机构信息

Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

出版信息

J Antimicrob Chemother. 2001 Apr;47(4):459-61. doi: 10.1093/jac/47.4.459.

DOI:10.1093/jac/47.4.459

PMID:11266421

Abstract

Antibiotic resistance in Helicobacter pylori varies according to geographical region. We studied the primary resistance rates among 652 H. pylori isolated from Korea in relation to collection date, disease presentation, age and gender. Resistance rates were 40.6% (metronidazole), 5.9% (clarithromycin), 5.3% (tetracycline), 0% (amoxycillin), 1.5% (furazolidone) and 1.5% (nitrofurantoin). Resistance to metronidazole and clarithromycin increased from 1994 to 1999 (from 33.3 to 47.7% and 4.8 to 7.7%, respectively), but the differences only reached significance when rates of metronidazole resistance in women were compared with those in men (48.6 versus 36.9%).

摘要

幽门螺杆菌的抗生素耐药性因地理区域而异。我们研究了从韩国分离出的652株幽门螺杆菌的主要耐药率与采集日期、疾病表现、年龄和性别的关系。耐药率分别为：甲硝唑40.6%、克拉霉素5.9%、四环素5.3%、阿莫西林0%、呋喃唑酮1.5%和呋喃妥因1.5%。1994年至1999年期间，对甲硝唑和克拉霉素的耐药性有所增加（分别从33.3%增至47.7%和4.8%增至7.7%），但只有在比较女性和男性甲硝唑耐药率时差异才具有统计学意义（48.6%对36.9%）。