Axon A T, Creamer B
Gut. 1975 Feb;16(2):99-104. doi: 10.1136/gut.16.2.99.
Various sugars were administered intravenously to rabbits and the rate of exsorption from plasma to intestinal lumen was measured. The exsorption rates of lactulose, mannose, and xylose were directly related to their plasma concentration but varied according to their molecular weight. Wglucose and galactose did not appear in the intestinal lumen until very high plasma concentrations were reached. The mucosal barrier which prevented glucose and galactose exsorption was abolished when luminal phlorizin M times 10-minus 2 or another actively absorbed sugar was placed in the lumen. 2:4 Dinitrophenol M times 10-minus 3 and the absence of the sodium ion did not impair the ffficiency of the barrier. When the plasma glucose concentration was raised to very high levels, glucose began to appear in the lumen; further increases in the glucose concentration then produced a rapid exsorption of glucose.
给兔子静脉注射各种糖类，并测量其从血浆到肠腔的外排速率。乳果糖、甘露糖和木糖的外排速率与其血浆浓度直接相关，但因分子量不同而有所变化。葡萄糖和半乳糖直到血浆浓度达到很高时才出现在肠腔中。当肠腔中放置10⁻²M的根皮苷或另一种主动吸收的糖类时，阻止葡萄糖和半乳糖外排的黏膜屏障被消除。10⁻³M的2:4二硝基苯酚和钠离子的缺失并不影响屏障的效率。当血浆葡萄糖浓度升高到非常高的水平时，葡萄糖开始出现在肠腔中；随后葡萄糖浓度的进一步升高导致葡萄糖快速外排。
