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HO-1 upregulation protects the pancreatic cell line betaTC3 from cytokines and Fas-induced apoptosis.

作者信息

Pileggi A, Cattan P, Berney T, Molano R D, Vizzardelli C, Ricordi C, Bach F H, Inverardi L

机构信息

Diabetes Research Institute, University of Miami School of Medicine, Miami, Florida, USA.

出版信息

Transplant Proc. 2001 Feb-Mar;33(1-2):266-7. doi: 10.1016/s0041-1345(00)02007-8.

DOI:10.1016/s0041-1345(00)02007-8
PMID:11266812
Abstract
摘要

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HO-1 upregulation protects the pancreatic cell line betaTC3 from cytokines and Fas-induced apoptosis.血红素加氧酶-1的上调可保护胰腺细胞系betaTC3免受细胞因子和Fas诱导的细胞凋亡。
Transplant Proc. 2001 Feb-Mar;33(1-2):266-7. doi: 10.1016/s0041-1345(00)02007-8.
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Heme oxygenase-1 gene transfer prevents CD95/FasL-mediated apoptosis and improves liver allograft survival via carbon monoxide signaling pathway.血红素加氧酶-1基因转移可通过一氧化碳信号通路预防CD95/FasL介导的细胞凋亡并提高肝移植存活率。
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Heme oxygenase-1 protects pancreatic beta cells from apoptosis caused by various stimuli.血红素加氧酶-1可保护胰腺β细胞免受各种刺激所引起的细胞凋亡。
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Expression of stress proteins heme oxygenase-1 and -2 in acute pancreatitis and pancreatic islet betaTC3 and acinar AR42J cells.
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Site of injury-directed induction of heme oxygenase-1 and -2 in experimental spinal cord injury: differential functions in neuronal defense mechanisms?实验性脊髓损伤中损伤部位定向诱导血红素加氧酶-1和-2：在神经元防御机制中的不同功能？
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Heme-induced heme oxygenase-1 (HO-1) in human monocytes inhibits apoptosis despite caspase-3 up-regulation.血红素诱导人单核细胞中的血红素加氧酶-1（HO-1），尽管半胱天冬酶-3上调，但仍能抑制细胞凋亡。
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引用本文的文献

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Current status of immunomodulatory and cellular therapies in preclinical and clinical islet transplantation.免疫调节和细胞疗法在临床前和临床胰岛移植中的现状
J Transplant. 2011;2011:637692. doi: 10.1155/2011/637692. Epub 2011 Oct 20.
2
The heme oxygenase-1 and c-FLIP in acute myeloid leukemias: two non-redundant but mutually exclusive cellular safeguards protecting cells against TNF-induced cell death?急性髓系白血病中的血红素加氧酶-1和c-FLIP：两种非冗余但相互排斥的细胞保护机制可保护细胞免受肿瘤坏死因子诱导的细胞死亡？
Oncotarget. 2010 Sep;1(5):317-319. doi: 10.18632/oncotarget.163.
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(GT)N dinucleotide repeat polymorphism of haem oxygenase-1 promotor region is not associated with inflammatory bowel disease risk or disease course.
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Clin Exp Immunol. 2008 Jul;153(1):81-5. doi: 10.1111/j.1365-2249.2008.03674.x. Epub 2008 May 5.
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Analysis of intestinal haem-oxygenase-1 (HO-1) in clinical and experimental colitis.临床和实验性结肠炎中肠道血红素加氧酶-1（HO-1）的分析
Clin Exp Immunol. 2005 Jun;140(3):547-55. doi: 10.1111/j.1365-2249.2005.02775.x.