急性髓系白血病中的血红素加氧酶-1和c-FLIP：两种非冗余但相互排斥的细胞保护机制可保护细胞免受肿瘤坏死因子诱导的细胞死亡？ - Suppr

Suppr

超能文献

The heme oxygenase-1 and c-FLIP in acute myeloid leukemias: two non-redundant but mutually exclusive cellular safeguards protecting cells against TNF-induced cell death?

作者信息

Shirley S, Micheau O

机构信息

INSERM, U866, Dijon, F-21079 France; Faculty of Medicine and Pharmacy, Univ. Bourgogne, Dijon, F-21079, France.

Centre Georges-François Leclerc, Dijon, F-21000, France.

出版信息

Oncotarget. 2010 Sep;1(5):317-319. doi: 10.18632/oncotarget.163.

DOI:10.18632/oncotarget.163

PMID:21307398

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3157731/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0e/3157731/ee553c5a44d0/oncotarget-01-317-g001.jpg

相似文献

The heme oxygenase-1 and c-FLIP in acute myeloid leukemias: two non-redundant but mutually exclusive cellular safeguards protecting cells against TNF-induced cell death?急性髓系白血病中的血红素加氧酶-1和c-FLIP：两种非冗余但相互排斥的细胞保护机制可保护细胞免受肿瘤坏死因子诱导的细胞死亡？

Oncotarget. 2010 Sep;1(5):317-319. doi: 10.18632/oncotarget.163.

FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism.人急性髓系白血病中FLIP对HO-1和TNF信号的调节提供了一种独特的继发性抗凋亡机制。

Oncotarget. 2010 Sep;1(5):359-366. doi: 10.18632/oncotarget.168.

Phorbol ester-induced PKCepsilon down-modulation sensitizes AML cells to TRAIL-induced apoptosis and cell differentiation.佛波酯诱导的蛋白激酶Cε下调使急性髓系白血病细胞对肿瘤坏死因子相关凋亡诱导配体（TRAIL）诱导的凋亡和细胞分化敏感。

Blood. 2009 Mar 26;113(13):3080-7. doi: 10.1182/blood-2008-03-143784. Epub 2008 Nov 6.

Contribution of the induction of heme oxygenase-1 to etoposide-induced apoptosis in acute myeloblastic leukemia.血红素加氧酶-1的诱导对依托泊苷诱导急性髓细胞白血病细胞凋亡的作用

Haematologica. 2003 Jan;88(1):112-3.

HO-1 underlies resistance of AML cells to TNF-induced apoptosis.血红素加氧酶-1是急性髓系白血病细胞对肿瘤坏死因子诱导的凋亡产生抗性的基础。

Blood. 2008 Apr 1;111(7):3793-801. doi: 10.1182/blood-2007-07-104042. Epub 2008 Jan 17.

J Biol Chem. 2012 Jan 2;287(1):641-649. doi: 10.1074/jbc.M111.286526. Epub 2011 Nov 15.

Protective effect of RIP and c-FLIP in preventing liver cancer cell apoptosis induced by TRAIL.RIP和c-FLIP在预防TRAIL诱导的肝癌细胞凋亡中的保护作用。

Int J Clin Exp Pathol. 2015 Jun 1;8(6):6519-25. eCollection 2015.

c-FLIP is involved in erythropoietin-mediated protection of erythroid-differentiated cells from TNF-alpha-induced apoptosis.c-FLIP 参与了促红细胞生成素介导的对红细胞分化细胞免受 TNF-α诱导的细胞凋亡的保护作用。

Cell Biol Int. 2010 May 4;34(6):621-30. doi: 10.1042/CBI20090085.

Prognostic and therapeutic relevance of c-FLIP in acute myeloid leukaemia.c-FLIP 在急性髓系白血病中的预后和治疗相关性。

Br J Haematol. 2013 Jan;160(2):188-98. doi: 10.1111/bjh.12108. Epub 2012 Nov 20.

Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells.Akt介导的c-FLIP和Mcl-1高表达赋予肺癌细胞对TRAIL诱导的细胞毒性的获得性抗性。

Mol Cancer Ther. 2008 May;7(5):1156-63. doi: 10.1158/1535-7163.MCT-07-2183.

引用本文的文献

Serum Tumor Necrosis Factor-Alpha Levels in Acute Leukemia and Its Prognostic Significance.急性白血病患者血清肿瘤坏死因子-α水平及其预后意义

Cureus. 2022 May 8;14(5):e24835. doi: 10.7759/cureus.24835. eCollection 2022 May.

Targeting the NRF2/HO-1 Antioxidant Pathway in FLT3-ITD-Positive AML Enhances Therapy Efficacy.靶向FLT3-ITD阳性急性髓系白血病中的NRF2/HO-1抗氧化途径可提高治疗效果。

Antioxidants (Basel). 2022 Apr 5;11(4):717. doi: 10.3390/antiox11040717.

CXXC5 (retinoid-inducible nuclear factor, RINF) is a potential therapeutic target in high-risk human acute myeloid leukemia.CXXC5（类视黄醇诱导核因子，RINF）是高危人类急性髓系白血病的一个潜在治疗靶点。

Oncotarget. 2013 Sep;4(9):1438-48. doi: 10.18632/oncotarget.1195.

The expression of heme oxygenase-1 in human-derived cancer cell lines.血红素加氧酶-1在人源癌细胞系中的表达。

Iran J Med Sci. 2011 Dec;36(4):260-5.

Systemic use of tumor necrosis factor alpha as an anticancer agent.将肿瘤坏死因子α作为抗癌剂进行全身应用。

Oncotarget. 2011 Oct;2(10):739-51. doi: 10.18632/oncotarget.344.

Pleiotropic functions of EAPII/TTRAP/TDP2: cancer development, chemoresistance and beyond.EAPII/TTRAP/TDP2 的多效性功能：癌症发展、化疗耐药性及其他。

Cell Cycle. 2011 Oct 1;10(19):3274-83. doi: 10.4161/cc.10.19.17763.

Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1.一线化疗药物诱导的急性髓系白血病细胞凋亡的保护作用是由血红素加氧酶-1介导的。

Oncotarget. 2011 Sep;2(9):658-68. doi: 10.18632/oncotarget.321.

本文引用的文献

Mechanisms of cell protection by heme oxygenase-1.血红素加氧酶-1 的细胞保护机制。

Annu Rev Pharmacol Toxicol. 2010;50:323-54. doi: 10.1146/annurev.pharmtox.010909.105600.

HO-1 activation can attenuate cardiomyocytic apoptosis via inhibition of NF-kappaB and AP-1 translocation following cardiac global ischemia and reperfusion.血红素氧合酶-1（HO-1）激活可通过抑制心脏整体缺血再灌注后核因子-κB（NF-κB）和激活蛋白-1（AP-1）的易位来减轻心肌细胞凋亡。

J Surg Res. 2009 Jul;155(1):147-56. doi: 10.1016/j.jss.2008.07.044. Epub 2008 Sep 4.

The Fas death signaling pathway connecting reactive oxygen species generation and FLICE inhibitory protein down-regulation.连接活性氧生成与FLICE抑制蛋白下调的Fas死亡信号通路。

J Immunol. 2008 Mar 1;180(5):3072-80. doi: 10.4049/jimmunol.180.5.3072.

HO-1 underlies resistance of AML cells to TNF-induced apoptosis.血红素加氧酶-1是急性髓系白血病细胞对肿瘤坏死因子诱导的凋亡产生抗性的基础。

Blood. 2008 Apr 1;111(7):3793-801. doi: 10.1182/blood-2007-07-104042. Epub 2008 Jan 17.

Elevated NF-kappaB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis.白血病淋巴细胞而非正常淋巴细胞中NF-κB反应和FLIP水平升高：水杨酸盐可降低其水平，使肿瘤坏死因子诱导的细胞凋亡得以发生。

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12790-5. doi: 10.1073/pnas.0701437104. Epub 2007 Jul 23.

Downregulation of c-FLIP promotes caspase-dependent JNK activation and reactive oxygen species accumulation in tumor cells.c-FLIP的下调促进肿瘤细胞中半胱天冬酶依赖性JNK激活和活性氧积累。

Oncogene. 2008 Jan 3;27(1):76-84. doi: 10.1038/sj.onc.1210624. Epub 2007 Jun 25.

Down-regulation of c-FLIP increases reactive oxygen species, induces phosphorylation of serine/threonine kinase Akt, and impairs motility of cancer cells.

Biotechnol Lett. 2007 Jan;29(1):141-7. doi: 10.1007/s10529-006-9213-5. Epub 2006 Dec 5.

Protection of human vascular smooth muscle cells from H2O2-induced apoptosis through functional codependence between HO-1 and AKT.通过血红素加氧酶-1（HO-1）与蛋白激酶B（AKT）之间的功能相互依赖保护人血管平滑肌细胞免受过氧化氢诱导的细胞凋亡。

Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2027-34. doi: 10.1161/01.ATV.0000236204.37119.8d. Epub 2006 Jul 13.

The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.c-FLIP氨基末端（p22-FLIP）诱导核因子κB激活。

J Exp Med. 2006 May 15;203(5):1295-305. doi: 10.1084/jem.20051556. Epub 2006 May 8.

FLICE-like inhibitory protein (FLIP) protects against apoptosis and suppresses NF-kappaB activation induced by bacterial lipopolysaccharide.类FLICE抑制蛋白（FLIP）可抵御细胞凋亡，并抑制细菌脂多糖诱导的核因子κB激活。

Am J Pathol. 2004 Oct;165(4):1423-31. doi: 10.1016/s0002-9440(10)63400-1.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验