Rikula U, Pänkälä L, Jalkanen L, Sihvonen L
Department of Virology and Epidemiology, National Veterinary and Food Research Institute, P.O. Box 45, FIN-00581, Helsinki, Finland.
Prev Vet Med. 2001 Apr 13;49(1-2):125-33. doi: 10.1016/s0167-5877(01)00177-5.
The most important farmed fur animal species in Finland are the American mink (Mustela vison), blue fox (Alopex lagopus), silver fox (Vulpes vulpes) and raccoon dog (Nyctereutes procyonoides); all are susceptible to canine distemper. The only distemper vaccines currently available are for mink, although they also have been used for fox and raccoon dogs in emergency situations. The efficacy in eliciting neutralizing antibodies and the safety of three mink-distemper vaccines were studied under field conditions with mink and silver fox. Two of the vaccines were also studied with raccoon dogs and blue fox. All three vaccines elicited a satisfactory antibody response in mink, whereas the response varied in the other species. No side effects were observed in any species tested. One of the vaccines was safe and immunogenic in all four species.
芬兰最重要的养殖毛皮动物种类是美洲水貂(鼬属水貂)、蓝狐(北极狐属北极狐)、银狐(狐属赤狐)和貉(Nyctereutes procyonoides);它们均易感染犬瘟热。目前唯一可用的犬瘟热疫苗是针对水貂的,不过在紧急情况下也用于狐狸和貉。在野外条件下,用美洲水貂和银狐对三种水貂犬瘟热疫苗激发中和抗体的效力及安全性进行了研究。其中两种疫苗也在貉和蓝狐身上进行了研究。所有三种疫苗在水貂身上均引发了令人满意的抗体反应,而在其他物种中的反应则有所不同。在所有受试物种中均未观察到副作用。其中一种疫苗在所有这四个物种中均安全且具有免疫原性。