Chappuis G
Rhône Mérieux, Laboratoire IFFA, Lyon, France.
Vet Microbiol. 1995 May;44(2-4):351-8. doi: 10.1016/0378-1135(95)00028-9.
Control of canine distemper can realistically only be achieved by the use of vaccination. The types of vaccine in current use are described, together with some of the problems encountered such as interference by maternal antibodies, and usage in species other than dogs. Modified live viral vaccines, as used for more than thirty years, have proved very effective. Nevertheless there is scope for some improvement in vaccine efficacy and recent developments in genetic recombinant methods are described.
犬瘟热的控制实际上只能通过接种疫苗来实现。本文描述了目前使用的疫苗类型,以及所遇到的一些问题,如母源抗体的干扰,以及在犬类以外物种中的使用情况。三十多年来一直使用的改良活病毒疫苗已被证明非常有效。然而,疫苗效力仍有一定的提升空间,本文还介绍了基因重组方法的最新进展。