A comparative clinical evaluation of trimethylpsoralen, psoralen and 8-methoxypsoralen in treating vitiligo.

Trimethylpsoralen, psoralen and 8-methoxypsoralen were adminstered in 10 mg dosage orally to 37, 29 and 23 patients with vitiligo. Complete improvement was noted in 8.9% and partial improvement was recorded in 59.5%. The overall results produced by trimethylpsoralen and psoralen were superior to those of 8-methoxypsoralen. There was no significant therapeutic difference noticed in regards to age, sex, duration and type of vitiligo.