Patel A R, Engstrom J E, Tusing L D, McNeeley K J, Chelimsky T C
Autonomic Laboratory, Department of Neurology, University Hospitals of Cleveland, and Case Western Reserve University, Cleveland, Ohio, USA.
Muscle Nerve. 2001 Apr;24(4):481-7. doi: 10.1002/mus.1030.
Lower body negative pressure (LBNP) may provide an alternative test of cardiovascular autonomic function for patients unable to perform the Valsalva maneuver (VM). LBNP at -40 mmHg for 30 s was compared to the VM at 40 mmHg for 15 s with heart rate and blood pressure measured continuously in three age groups: 10-25 years; 26-40 years; and 41-55 years. Heart rate and blood pressure responses were comparable, with moderately diminished changes in blood pressure and heart rate in the LBNP test. When heart response to LBNP was converted to a ratio similar to that calculated for the VM, a high degree of correlation was found (R(2) = 0.5711). The LBNP test shows promise as an alternative test of cardiovascular autonomic function based on studies in normal subjects. The less marked changes may relate to the more passive nature of the applied stress. Future work should improve the device's accessibility and establish values for patients with autonomic disorders.
对于无法进行瓦尔萨尔瓦动作（VM）的患者，下体负压（LBNP）可能提供一种心血管自主神经功能的替代测试方法。将-40 mmHg的LBNP持续30秒与40 mmHg的VM持续15秒进行比较，并在三个年龄组中连续测量心率和血压：10 - 25岁；26 - 40岁；以及41 - 55岁。心率和血压反应具有可比性，在LBNP测试中血压和心率的变化略有减弱。当将对LBNP的心率反应转换为与VM计算的比率相似的比率时，发现高度相关性（R(2) = 0.5711）。基于对正常受试者的研究，LBNP测试有望成为心血管自主神经功能的替代测试方法。较不明显的变化可能与所施加压力的更被动性质有关。未来的工作应提高该设备的可及性，并为自主神经功能障碍患者确定相关数值。
