Mullins C, Bonifacino J S
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Bioessays. 2001 Apr;23(4):333-43. doi: 10.1002/bies.1048.
The lysosome serves as a site for delivery of materials targeted for removal from the eukaryotic cell. The mechanisms underlying the biogenesis of this organelle are currently the subject of renewed interest due to advances in our understanding of the protein sorting machinery. Genetic model systems such as yeast and Drosophila have been instrumental in identifying both protein and lipid components of this machinery. Importantly, many of these components, as well as the processes in which they are involved, are proving conserved in mammals. Other recently identified components, however, appear to be unique to higher eukaryotes. BioEssays 23:333-343, 2001. Published 2001 John Wiley & Sons, Inc.
溶酶体是真核细胞中用于输送需清除物质的场所。由于我们对蛋白质分选机制的理解取得了进展，这种细胞器生物发生的潜在机制目前再次成为人们关注的焦点。酵母和果蝇等遗传模型系统在鉴定该机制的蛋白质和脂质成分方面发挥了重要作用。重要的是，这些成分中的许多以及它们所参与的过程在哺乳动物中被证明是保守的。然而，其他最近鉴定出的成分似乎是高等真核生物所特有的。《生物论文》23:333 - 343，2001年。2001年由约翰·威利父子公司出版。
