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基于柱前衍生化和非对映异构体形成的高效液相色谱法用于药物对映体拆分的手性衍生化试剂：对映选择性及相关结构

Chiral derivatization reagents for drug enantioseparation by high-performance liquid chromatography based upon pre-column derivatization and formation of diastereomers: enantioselectivity and related structure.

作者信息

Sun X X, Sun L Z, Aboul-Enein H Y

机构信息

Department of Chemical Engineering, Jiangsu Institute of Petrochemical Technology, Changzhou 213016, People's Republic of China.

出版信息

Biomed Chromatogr. 2001 Apr;15(2):116-32. doi: 10.1002/bmc.41.

DOI:10.1002/bmc.41
PMID:11268052
Abstract

Structures and related enantioselectivities of the respective chiral derivatization reagents (CDRs) for drug enantioseparation by high-performance chromatography based upon pre-column derivatization and diastereomeric formation are reviewed. The elution order of diastereomers caused reaction of some CDRs with enantiomeric amino acids and carboxylic acids. The development of new CDRs available for indirect HPLC methods is also discussed. (c) 2001 John Wiley & Sons, Ltd.

摘要

综述了基于柱前衍生化和非对映体形成的高效色谱法拆分药物对映体时，各手性衍生化试剂（CDR）的结构及相关对映选择性。一些CDR与对映体氨基酸和羧酸的反应导致了非对映体的洗脱顺序。还讨论了可用于间接高效液相色谱法的新型CDR的开发。（c）2001约翰·威利父子有限公司

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2
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