血根碱对小鼠脑内单胺氧化酶活性的抑制作用。

Inhibitory effects of sanguinarine on monoamine oxidase activity in mouse brain.

作者信息

Lee S S, Kai M, Lee M K

机构信息

College of Pharmacy, Chungbuk National University, San 48, Kaeshin-Dong, Heungduk-Ku, Cheongju 361-763, Republic of Korea.

出版信息

Phytother Res. 2001 Mar;15(2):167-9. doi: 10.1002/ptr.703.

DOI:10.1002/ptr.703

PMID:11268121

Abstract

The effects of benzophenanthridine alkaloids, such as sanguinarine and chelidonine, on monoamine -oxidase (MAO) activity in mouse brain were investigated. Sanguinarine showed an inhibitory effect on MAO activity in a concentration dependent manner (53.4% inhibition at 25 microM). However, chelidonine did not inhibit MAO activity. The IC(50) value of sanguinarine was 24.5 microM. Sanguinarine inhibited non-competitively MAO activity using kynuramine as a substrate. The K(i) value for sanguinarine was 22.1 microM. These results suggest that sanguinarine partially contributes to the regulation of catecholamine content.

摘要

研究了血根碱和白屈菜碱等苯并菲啶生物碱对小鼠脑组织中单胺氧化酶（MAO）活性的影响。血根碱对MAO活性呈现浓度依赖性抑制作用（在25微摩尔时抑制率为53.4%）。然而，白屈菜碱并未抑制MAO活性。血根碱的半数抑制浓度（IC50）值为24.5微摩尔。以犬尿胺为底物时，血根碱对MAO活性呈非竞争性抑制。血根碱的抑制常数（Ki）值为22.1微摩尔。这些结果表明血根碱对儿茶酚胺含量的调节有一定作用。