Caine R, Albert D M, Lahav M, Bullock J
Invest Ophthalmol. 1975 May;14(5):359-63.
The clinical picture resembling fundus albipunctatus was seen to develop in rabbits following subcutaneous injection with dibutyl oxalate. On histologic examination, the flecks were found to be due to intracellular accumulation of calcium oxalate in the RPE cells. The clinical and histologic features of this animal model closely resemble the recently described entity of oxalate retinopathy in humans which was seen in the presence of high circulating oxalate levels. It is suggested that the presence of metabolic disorders or toxicity which are known to cause oxalate depositions should be sought in patients with fundus albipunctatus.
皮下注射草酸二丁酯后，兔子眼底出现类似白点状眼底的临床表现。组织学检查发现，这些斑点是由于视网膜色素上皮（RPE）细胞内草酸钙积聚所致。该动物模型的临床和组织学特征与最近描述的人类草酸视网膜病变极为相似，后者见于循环草酸水平升高的情况。建议在白点状眼底患者中寻找已知会导致草酸盐沉积的代谢紊乱或毒性因素。
