Cascinu S, Graziano F, Catalano V, Valentini M, Rossi M C, Baldelli A M, Ghiselli R, Saba V, Giordani P, Catalano G
Azienda Ospedale S. Salvatore, Ospedale Muraglia, Via Lombroso, 61100 Pesaro, Italy.
Anticancer Res. 2000 Sep-Oct;20(5C):3839-42.
The prognosis of patients with T3N0M0 gastric cancer is still unfavourable and the role of adjuvant chemotherapy is unclear. We addressed this study to evaluate whether the analysis of the S-Phase Fraction (SPF) might have prognostic implications in serosa-positive, node-negative gastric cancer.
Specimens of resected gastric cancer were studied by flow cytometry for SPF analysis. Consecutive patients with stage pT3N0M0, adequate follow-up information and sufficient archival tumor tissue were considered eligible for the study. The tumor SPF indices were related to the timing of recurrences, the relapse rate and the disease-free survival of patients.
The analysis was carried out on samples of 137 patients with surgically-resected, stage pT3N0M0 gastric cancer. SPF resulted high and low in 39% and 61% of cases, respectively. Fifty-seven patients relapsed (42%) and early recurrences (within 18 months after surgery) occurred more frequently among cases with high SPF (p < .03). Patients with high SPF tumors showed a worse relapse rate and disease-free survival than patients with low SPF tumors. (p < .005).
The SPF analysis showed prognostic differences among patients with stage pT3N0M0 gastric cancer. These data may be of value in the planning of future adjuvant chemotherapy trials in gastric cancer.
T3N0M0期胃癌患者的预后仍然不佳，辅助化疗的作用尚不清楚。我们开展这项研究以评估S期分数（SPF）分析对浆膜阳性、淋巴结阴性胃癌患者是否具有预后意义。
通过流式细胞术对切除的胃癌标本进行SPF分析。连续纳入pT3N0M0期、有充分随访信息且有足够存档肿瘤组织的患者作为本研究的合格对象。肿瘤SPF指数与患者复发时间、复发率和无病生存期相关。
对137例接受手术切除的pT3N0M0期胃癌患者的样本进行了分析。SPF结果显示，分别有39%和61%的病例SPF高和低。57例患者复发（42%），SPF高的病例中早期复发（术后18个月内）更为常见（p < 0.03）。SPF高的肿瘤患者比SPF低的肿瘤患者显示出更差的复发率和无病生存期（p < 0.005）。
SPF分析显示pT3N0M0期胃癌患者之间存在预后差异。这些数据可能对未来胃癌辅助化疗试验的规划具有价值。
