核糖霉素（SF - 733）的生物转化。III. 3 - N - 羧甲基核糖霉素的形成、结构与合成。
Bioconversion of ribostamycin (SF-733). III. Formation, structure and synthesis of 3-N-carboxymethyl ribostamycin.
作者信息
Kojima M, Inouye S, Nida T
出版信息
J Antibiot (Tokyo). 1975 Jan;28(1):48-55. doi: 10.7164/antibiotics.28.48.
PMID:1126867
Abstract
A new inactivated product of ribostamycin (SF-733), 3-N-carboxymethyl ribostamycin, was obtained from the broth of Streptomyces ribosidificus which was grown on a medium containing D-xylose. Detection and some biochemical mechanism of N-carboxymethylation were discussed, and structure of 3-N-carboxymethyl ribostamycin was proposed based on the chemical degradation and synthesis.
摘要
一种新的核糖霉素灭活产物（SF - 733），即3 - N - 羧甲基核糖霉素，是从在含有D - 木糖的培养基上生长的产核糖链霉菌肉汤中获得的。讨论了N - 羧甲基化的检测及一些生化机制，并基于化学降解和合成对3 - N - 羧甲基核糖霉素的结构进行了推测。
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