Dawson C A, Forrester T E, Hamilton L H
J Appl Physiol. 1975 May;38(5):811-6. doi: 10.1152/jappl.1975.38.5.811.
Using an isolated perfused cat lung preparation we examined the effects of hypoxia and histamine infusion on the lung blood volume. Total lung blood volume was determined from the indocyanine green transit time and the ether bolus technique was used to estimate arterial and venous volumes during forward and retrograde perfusion, respectively. Changes in lung total fluid content were determined from changes in the blood volume of the perfusion system. Hypoxia increased perfusion pressure and decreased total fluid and blood volume. Histamine infusion also increased perfusion pressure and decreased blood volume. However, histamine increased total fluid volume, indicating an increase in vascular permeability. Hypoxia decreased arterial and venous volumes, and histamine decreased venous volume. The slopes of the arterial and venous volume/pressure curves were not altered by hypoxia or histamine.
利用离体灌流猫肺标本，我们研究了低氧和输注组胺对肺血容量的影响。通过吲哚菁绿通过时间测定肺总血容量，并分别采用乙醚团注技术在正向和逆向灌流期间估计动脉血容量和静脉血容量。根据灌流系统血容量的变化确定肺总液体含量的变化。低氧增加灌流压力，降低总液体量和血容量。输注组胺也增加灌流压力并降低血容量。然而，组胺增加了总液体量，表明血管通透性增加。低氧降低动脉血容量和静脉血容量，组胺降低静脉血容量。低氧或组胺未改变动脉血容量/压力曲线和静脉血容量/压力曲线的斜率。
