Rippe B, Allison R C, Parker J C, Taylor A E
J Appl Physiol Respir Environ Exerc Physiol. 1984 Jul;57(1):223-32. doi: 10.1152/jappl.1984.57.1.223.
The action of histamine (H), serotonin (5-HT), and norepinephrine (NE) on the lung vasculature was evaluated in isolated blood-perfused dog lung lobes using isogravimetric techniques. Pre- and postcapillary resistances, isogravimetric capillary pressure (Pc,i), capillary filtration pressure (Pc,f), capillary filtration coefficient (Kf,c), and vascular pressure-volume relationships were measured. For constant-flow conditions, all drugs induced marked increases in both pre- and postcapillary resistances and increased Pc,f. The rise in Pc,f was most pronounced for H and least marked for NE and 5-HT. For constant-pressure perfusion, Pc,f increased slightly for H but not for NE and 5-HT, while total vascular resistance increased 4-5 times for all drugs. Vascular distensibility and volumes decreased markedly for NE and 5-HT but only slightly for H. None of the drugs appeared to alter capillary permeability because Kf,c and Pc,i measured during the infusions were not different from control.
使用等重量技术，在离体血液灌注的犬肺叶中评估了组胺（H）、血清素（5-羟色胺，5-HT）和去甲肾上腺素（NE）对肺血管系统的作用。测量了毛细血管前和毛细血管后的阻力、等重量毛细血管压力（Pc,i）、毛细血管滤过压力（Pc,f）、毛细血管滤过系数（Kf,c）以及血管压力-容积关系。在恒流条件下，所有药物均使毛细血管前和毛细血管后的阻力显著增加，并使Pc,f升高。Pc,f的升高对H最为明显，对NE和5-HT则最不明显。在恒压灌注时，H使Pc,f略有升高，而NE和5-HT则无此作用，而所有药物均使总血管阻力增加4至5倍。NE和5-HT使血管扩张性和容积显著降低，而H仅使其略有降低。所有药物似乎均未改变毛细血管通透性，因为输注期间测量的Kf,c和Pc,i与对照组无差异。
