Rehder K, Abboud N, Rodarte J R, Hyatt R E
J Appl Physiol. 1975 May;38(5):896-9. doi: 10.1152/jappl.1975.38.5.896.
Static transpulmonary pressure (Pao-Pes) and the vertical gradient of transpulmonary pressure were determined in five sitting conscious normal subjects at mean airway pressures of 0 (ambient), 11, and 21 cmH2O. All subjects exhibited a nonuniform transpulmonary pressure gradient down the esophagus. The vertical pressure gradient was consistently larger in the lower (8-20cm below esophageal artifact) than in the middle region (0-8cm) of the esophagus. The gradient was not significantly altered by continuous positive airway pressure (11 and 21 cmH2O) or by changes in lung volume (60, 70, and 80% of total lung capacity (TLC)). Continuous positive airway pressure also did not result in a consistent change of the overall static pressure-volume curve of the lung. There was a small but statistically significant increase in TLC with each increase in airway pressure.
在5名清醒坐姿正常受试者中，分别在平均气道压力为0（环境压力）、11和21 cmH₂O时测定了静态跨肺压（Pao - Pes）和跨肺压的垂直梯度。所有受试者食管全长的跨肺压梯度均不一致。食管下部（食管伪迹下方8 - 20 cm）的垂直压力梯度始终大于食管中部（0 - 8 cm）。持续气道正压（11和21 cmH₂O）或肺容积变化（肺总量（TLC）的60%、70%和80%）均未显著改变该梯度。持续气道正压也未导致肺整体静态压力 - 容积曲线的一致变化。随着气道压力每次升高，TLC有小幅但具有统计学意义的增加。
