Miletich D J, Ivankovic A D, Albrecht R F, Toyooka E T
J Appl Physiol. 1975 May;38(5):942-5. doi: 10.1152/jappl.1975.38.5.942.
Changes in cerebral and extracerebral blood flow in the goat after ligation of the internal maxillary artery and deliberate thrombosis of the extracerebral arteries (buccinator, ethmoidal, and ophthalmic) with thrombin were compared to changes seen in animals after internal maxillary artery ligation only and in normal animals where no surgical manipulations were performed. Blood flow was measured by injecting 51-Cr-labeled microspheres into the internal maxillary artery via a catheter placed into the temporal artery. Analysis of the radioactivity in extracerebral and intracerebral tissues indicated that when the internal maxillary artery is ligated and the extracerebral arteries are thrombosed, virtually all of the blood flow from the carotid artery is destined from the brain. However, if only the internal maxillary artery is ligated nearly one-fourth of the blood flow from the maxillary travels to extra-cerebral tissues. In normal animals, it was determined that only one-fourth of the blood flow in the internal maxillary is destined for the cerebral circulation. Results from this study indicate that if the former method is employed an accurate measure of cerebral blood flow is possible without the complications of extra-cerebral flow. If the latter technique is used care must be taken in evaluating cerebral blood flow since a large component of extra-cerebral blood flow is present.
将山羊的上颌内动脉结扎，并通过凝血酶使脑外动脉（颊肌动脉、筛动脉和眼动脉）形成血栓，将由此导致的脑内和脑外血流变化，与仅进行上颌内动脉结扎的动物以及未进行任何手术操作的正常动物所观察到的变化进行比较。通过将51 - 铬标记的微球经置于颞动脉的导管注入上颌内动脉来测量血流。对脑外和脑内组织放射性的分析表明，当结扎上颌内动脉并使脑外动脉形成血栓时，来自颈动脉的几乎所有血流都流向脑部。然而，如果仅结扎上颌内动脉，来自上颌的血流近四分之一会流向脑外组织。在正常动物中，确定上颌内动脉中只有四分之一的血流进入脑循环。本研究结果表明，如果采用前一种方法，有可能准确测量脑血流量，而不会出现脑外血流的并发症。如果使用后一种技术，在评估脑血流量时必须小心，因为存在大量的脑外血流。
