Herrmann J L, Rastelli L, Burgess C E, Fernandez E E, Rothberg B E, Rothberg J M, Shimkets R A
Department of Internal Discovery, CuraGen Corporation, New Haven Connecticut 06511, USA.
Cancer J. 2001 Jan-Feb;7(1):40-51.
The explosion of information generated by large-scale functional genomics technologies has resulted in an exponential increase in the number of potential genes and proteins available for pharmaceutical and diagnostic research development. In order to tap this potential, the primary challenge is to develop a strategy to effectively integrate and extract meaning from the human genomic sequence information that has been generated since the start of the Human Genome Project. This article deals with the strategies being applied by academics and by the biotechnology sector to sort and triage this information with the ultimate goal of identifying future therapeutic targets for cancer and other diseases.
大规模功能基因组学技术所产生的信息爆炸，已导致可用于药物和诊断研究开发的潜在基因和蛋白质数量呈指数级增长。为了挖掘这一潜力，首要挑战是制定一种策略，以有效地整合人类基因组序列信息并从中提取有意义的内容，这些信息自人类基因组计划启动以来就已产生。本文探讨了学术界和生物技术领域正在应用的策略，对这些信息进行分类和筛选，最终目标是确定癌症和其他疾病未来的治疗靶点。
