West C M L, Elliott R M, Burnet N G
Academic Radiation Oncology, University of Manchester, Christie Hospital NHS Trust, Manchester M20 4BX, UK.
Clin Oncol (R Coll Radiol). 2007 Aug;19(6):470-80. doi: 10.1016/j.clon.2007.02.016. Epub 2007 Apr 6.
The expansion of our knowledge through the Human Genome Project has been accompanied by the development of new high-throughput techniques, which provide extensive capabilities for the analysis of a large number of genes or the whole genome. These assays can be carried out in various clinical samples at the DNA (genome), RNA (transcriptome) or protein (proteome) level. There is a belief that this genomic revolution, i.e. sequencing of the human genome and developments in high-throughput technology, heralds a future of personalised medicine. For clinical oncology, this progress should increase the possibility of predicting individual patient responses to radiotherapy. This review highlights some of the work involving sparsely ionising radiation and the new technologies.
通过人类基因组计划，我们的知识得到了扩展，与此同时，新的高通量技术也在不断发展，这些技术为分析大量基因或整个基因组提供了广泛的能力。这些检测可以在DNA（基因组）、RNA（转录组）或蛋白质（蛋白质组）水平的各种临床样本中进行。人们相信，这场基因组革命，即人类基因组测序和高通量技术的发展，预示着个性化医疗的未来。对于临床肿瘤学来说，这一进展将增加预测个体患者对放疗反应的可能性。本综述重点介绍了一些涉及低电离辐射和新技术的研究工作。
