Schaefer C, Grouse L, Buetow K, Strausberg R L
Center for Bioinformatics, National Cancer Institute, Bethesda, Maryland 20892-2590, USA.
Cancer J. 2001 Jan-Feb;7(1):52-60.
The National Cancer Institute's Cancer Genome Anatomy Project (CGAP) is developing publicly accessible information, technology, and material resources that provide a platform for the interface of cancer research and genomics. CGAP's efforts have focused toward (1) building and annotating catalogues of genes expressed during cancer development, (2) identifying polymorphisms in those genes, and (3) developing resources for the molecular characterization of cancer-related chromosomal aberrations. To date, CGAP has produced more than 1,000,000 expressed sequence tags, approximately 3,300,000 serial analysis of gene expression tags, and identified more than 10,000 human gene-based single-nucleotide polymorphisms. To enhance access to these datasets by the research community, a new Cancer Genome Project web site (http://cgap.nci.nih.gov/) is being introduced. The web site includes genomic data for humans and mice, including transcript sequence, gene expression patterns, single-nucleotide polymorphisms, clone resources, and cytogenetic information. Descriptions of the methods and reagents used in deriving the CGAP datasets are also provided. An extensive suite of informatics tools facilitates queries and analysis of the CGAP data by the community. One of the newest features of the CGAP web site is an electronic version of the Mitelman Database of Chromosome Aberrations in Cancer.
美国国立癌症研究所的癌症基因组解剖计划（CGAP）正在开发可公开获取的信息、技术和物质资源，为癌症研究与基因组学的交叉提供一个平台。CGAP的工作重点包括：（1）构建并注释癌症发生过程中表达的基因目录；（2）识别这些基因中的多态性；（3）开发用于癌症相关染色体畸变分子特征分析的资源。迄今为止，CGAP已产生了超过100万个表达序列标签、约330万个基因表达序列分析标签，并识别出超过10000个人类基因单核苷酸多态性。为方便研究团体获取这些数据集，一个新的癌症基因组计划网站（http://cgap.nci.nih.gov/）即将推出。该网站包括人类和小鼠的基因组数据，涵盖转录本序列、基因表达模式、单核苷酸多态性、克隆资源和细胞遗传学信息。还提供了用于生成CGAP数据集的方法和试剂的描述。一套广泛的信息学工具便于研究团体对CGAP数据进行查询和分析。CGAP网站的最新功能之一是癌症染色体畸变米特尔曼数据库的电子版。
