Halloul Z, Meyer F, Lippert H, Buerger T
Department of Surgery, University Hospital of Magdeburg, Otto von Guericke University, Germany.
Angiology. 2001 Mar;52(3):217-21. doi: 10.1177/000331970105200310.
Ergotamine-containing drugs are widely used in the treatment of acute migraine attacks. Spastic vasoconstriction is one of the possible side effects usually affecting the lower extremities and sometimes leading to gangrene. A 28-year-old woman was hospitalized for severe acute arterial insufficiency of the limbs. The initial surgical approach was not successful since the diagnosis was missed. Overuse of ergotamine derivative was acknowledged by the patient, who had a long history of migraine headaches. Therefore, the patient was treated conservatively with intravenous heparin and prostaglandin infusion and sympatheticolysis via epidural catheter. The vascular complications, angiographic findings, and different modalities of treatment of ergotamine-induced peripheral vascular insufficiency of the lower limb are reviewed.
含麦角胺的药物被广泛用于治疗急性偏头痛发作。痉挛性血管收缩是一种可能的副作用，通常影响下肢，有时会导致坏疽。一名28岁女性因严重的急性肢体动脉供血不足住院。由于误诊，最初的手术方法未成功。患者承认长期过度使用麦角胺衍生物，其有偏头痛病史。因此，对该患者采用静脉注射肝素、前列腺素输注以及通过硬膜外导管进行交感神经松解术进行保守治疗。本文回顾了麦角胺引起的下肢周围血管功能不全的血管并发症、血管造影表现及不同治疗方式。
