[炎症中白细胞对红细胞生成的调节机制]
[Regulatory mechanisms of erythropoiesis by leukocytes in inflammation].
作者信息
Klimenko M O, Shevchenko O M
机构信息
Kharkov State Medical University, Ukraininan Ministry of Health, Kharkov, Ukraine.
出版信息
Fiziol Zh (1994). 2000;46(5):41-6.
PMID:11269852
Abstract
On the model of carrageenan-induced acute aseptic peritonitis in rats with use of the inhibitors of some leukocytic products it is shown that lysosomal proteinases inhibit erythropoiesis activation in inflammation. Lipoxygenase metabolites stimulate erythropoiesis. Eicosanoids as a whole stimulate erytropoiesis still more. Reactive oxygen species promote the development of erythron hyperplasia. Dexamethasone administration increases the erythropoiesis intensification.
摘要
在利用某些白细胞产物抑制剂建立的角叉菜胶诱导的大鼠急性无菌性腹膜炎模型中，研究表明溶酶体蛋白酶可抑制炎症中红细胞生成的激活。脂氧合酶代谢产物刺激红细胞生成。整体而言，类花生酸更能刺激红细胞生成。活性氧促进红细胞增生的发展。给予地塞米松可增强红细胞生成。
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