支配大鼠腰椎小关节的P物质和降钙素基因相关肽免疫反应性感觉背根神经节神经元。
Substance P and calcitonin gene-related peptide immunoreactive sensory DRG neurons innervating the lumbar facet joints in rats.
作者信息
Ohtori S, Takahashi K, Chiba T, Yamagata M, Sameda H, Moriya H
机构信息
Department of Orthopaedic Surgery, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8677, Japan.
出版信息
Auton Neurosci. 2000 Dec 28;86(1-2):13-7. doi: 10.1016/S1566-0702(00)00194-6.
The rat L5/6 facet joint is innervated from L1 to L5 dorsal root ganglions (DRGs) multisegmentally. Sensory fibers from L1 and L2 DRGs were reported to innervate nonsegmentally through the paravertebral sympathetic trunks, while those from L3 to L5 DRGs segmentally innervate the L5/6 facet joint. The presence of substance P (SP) and calcitonin gene-related peptide (CGRP) immunoreactive (ir) nerve fibers has been demonstrated in the lumber facet joints, but their ratios have not been determined. Fluoro-gold (F-G) labeled neurons innervating the L5/6 facet joint were distributed throughout the DRGs for levels L1 to L5. Of the F-G labeled neurons, the ratios of SP-ir L1, L2, L3, L4 and L5 DRG neurons were 13, 15, 29, 31 and 30%, respectively, and those of CGRP-ir neurons were 17, 24, 44, 56 and 50%, respectively. The ratios of SP and CGRP-ir neurons in L1 and L2 DRGs were significantly less than those in L3, L4 or L5 DRGs. In conclusion, the neurons of L3, L4 and L5 DRGs may have a more significant role in pain sensation of the facets than L1 and L2 DRG neurons.
大鼠L5/6小关节由L1至L5背根神经节（DRG）多节段地支配。据报道，来自L1和L2 DRG的感觉纤维通过椎旁交感干非节段性地支配，而来自L3至L5 DRG的纤维则节段性地支配L5/6小关节。在腰椎小关节中已证实存在P物质（SP）和降钙素基因相关肽（CGRP）免疫反应性（ir）神经纤维，但它们的比例尚未确定。支配L5/6小关节的氟金（F-G）标记神经元分布在L1至L5水平的整个DRG中。在F-G标记的神经元中，SP-ir L1、L2、L3、L4和L5 DRG神经元的比例分别为13%、15%、29%、31%和30%，CGRP-ir神经元的比例分别为17%、24%、44%、56%和50%。L1和L2 DRG中SP和CGRP-ir神经元的比例显著低于L3、L4或L5 DRG中的比例。总之，与L1和L2 DRG神经元相比，L3、L4和L5 DRG的神经元在小关节疼痛感觉中可能起更重要的作用。
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