Furuya A, Matsukawa T, Ozaki M, Nishiyama T, Kume M, Kumazawa T
Department of Anaesthesia, Yamanashi Medical University, Yamanashi, Japan.
Eur J Anaesthesiol. 2001 Feb;18(2):88-92. doi: 10.1046/j.0265-0215.2000.00784.x.
To investigate whether the administration of ketamine before induction with propofol produces a smaller decrease in arterial pressure.
Twenty-two patients were assigned to one of two groups to receive either propofol with ketamine (n = 11) or propofol alone (n = 11, control). Anaesthesia was induced with 2 mg kg-1 propofol and 0.5 mg kg-1 ketamine or 2 mg kg-1 propofol alone. Ketamine was administered 1 min prior to induction with propofol. Immediately after induction with propofol, vecuronium (0.15 mg kg-1) was administered. Four minutes after administration of vecuronium, tracheal intubation was performed. Anaesthesia was maintained using sevoflurane (0.5%) in 66% nitrous oxide until 3 min after intubation. Systolic, diastolic and mean arterial pressure and heart rate were recorded on arrival, directly before induction with propofol, prior to tracheal intubation, immediately after intubation and at 3 min after intubation.
Administration of ketamine before induction with propofol preserved haemodynamic stability compared with induction with propofol alone.
研究在使用丙泊酚诱导前给予氯胺酮是否能使动脉压下降幅度更小。
22例患者被分为两组，分别接受丙泊酚联合氯胺酮（n = 11）或单纯丙泊酚（n = 11，对照组）。采用2 mg·kg-1丙泊酚和0.5 mg·kg-1氯胺酮或仅用2 mg·kg-1丙泊酚诱导麻醉。氯胺酮在丙泊酚诱导前1分钟给予。丙泊酚诱导后立即给予维库溴铵（0.15 mg·kg-1）。给予维库溴铵4分钟后进行气管插管。使用66%氧化亚氮中的七氟醚（0.5%）维持麻醉直至插管后3分钟。记录到达时、丙泊酚诱导前、气管插管前、插管后即刻及插管后3分钟时的收缩压、舒张压、平均动脉压和心率。
与单纯丙泊酚诱导相比，在丙泊酚诱导前给予氯胺酮可维持血流动力学稳定。
