蒙脱石K10催化超声促进的二硬脂基醚的制备

Ultrasound-promoted preparation of disteryl ethers catalyzed by montmorillonite K 10.

作者信息

Li J T, Li T S, Li L J, Yang Z Q

机构信息

Department of Chemistry, Hebei University, Baoding 071002, People's Republic of China.

出版信息

Ultrason Sonochem. 1998 Jun;5(2):83-5. doi: 10.1016/s1350-4177(98)00010-8.

DOI:10.1016/s1350-4177(98)00010-8

PMID:11270342

Abstract

In the presence of montmorillonite K 10, 5(6)-unsaturated sterols (1) were heated under ultrasound at 45 degrees C in dichloromethane for 2-5.5 h to provide 3 beta,3'beta-5(6)/5'(6')-unsaturated disteryl ethers (2) in 35-79% yield. Meanwhile, 3 alpha,3'alpha-diandrost-5-en-17-one-3-yl ether (3a) and 3 alpha,3'alpha-dipregn-5-en-20-one-3-yl ether (3b) were also obtained as by-products from 3 beta-hydroxyl-androst-5-en-17-one (1a) and 3 beta-hydroxyl-pregnan-5-en-20-one (1b) respectively.

摘要

在蒙脱石K 10存在的情况下，将5(6)-不饱和甾醇(1)于二氯甲烷中在45℃下超声加热2 - 5.5小时，以35 - 79%的产率得到3β,3'β-5(6)/5'(6')-不饱和二甾基醚(2)。同时，还分别从3β-羟基-雄甾-5-烯-17-酮(1a)和3β-羟基-孕甾-5-烯-20-酮(1b)中分别得到副产物3α,3'α-二雄甾-5-烯-17-酮-3-基醚(3a)和3α,3'α-二孕甾-5-烯-20-酮-3-基醚(3b)。