Vieira M R, Milheiro A, Pacheco F A
Dermatology Department, Curry Cabral Hospital, Lisbon, Portugal.
Med Mycol. 2001 Feb;39(1):135-7. doi: 10.1080/mmy.39.1.135.137.
Phaeohyphomycosis is a clinical entity caused by dematiaceous fungi. We describe a clinical case of phaeohyphomycosis due to Cladosporium cladosporioides in a 45-year-old white male, apparently healthy, human immunodeficiency virus-negative. The patient was treated with terbinafine for 9 months, with regression of a skin lesion. Three months after discontinuation of the therapy, there was a clinical and mycological relapse. After progression of the disease with inadequate treatment, there was no response to amphotericin B and flucytosine. Finally, we obtained a clinical response with itraconazole oral solution at 600 mg day(-1) for a 6-month period.
暗色丝孢霉病是一种由暗色真菌引起的临床病症。我们描述了一例由枝孢霉引起的暗色丝孢霉病的临床病例，患者为一名45岁表面健康的白人男性，人类免疫缺陷病毒检测呈阴性。该患者接受了9个月的特比萘芬治疗，皮肤病变有所消退。停药3个月后，出现了临床和真菌学复发。在治疗不充分导致病情进展后，两性霉素B和氟胞嘧啶治疗无效。最后，患者口服伊曲康唑溶液，每日600毫克，持续6个月，获得了临床缓解。
