Murakami T, Kim T, Takamura M, Shimizu J, Hori M, Dono K, Takachi K, Kato N, Miyazawa T, Sakon M, Monden M, Nakamura H
Department of Radiology, Osaka University Medical School, Japan.
Dig Dis Sci. 2001 Jan;46(1):148-55. doi: 10.1023/a:1005585101620.
The purpose of this study was to investigate whether regional liver damage could be detected by means of enhanced MR imaging with a superparamagnetic iron oxide (SH U 555A) in an ischemia-reperfusion model of rat liver. Ischemic liver damage was induced in the right lobe by vascular clamping for 0 (sham), 30 (I-30), 60 (I-60), and 90 minutes (I-90). There was no significant difference in relative enhancement (RE) between the ischemic and nonischemic lobes in the sham, I-30 and I-60 groups, while RE of the ischemic lobe was significantly lower than that of its nonischemic counterpart in the I-90 group as seen on SH U 555A enhanced proton density spin echo images (P < 0.05). Histological examination revealed that iron deposits were significantly smaller in the ischemic than the nonischemic lobe in the I-90 group (P < 0.05), although there was no significant difference in the number of Kupffer cells. Our results indicate that severe regional liver damage can be evaluated by MR imaging with SH U 555A.
本研究的目的是探讨在大鼠肝脏缺血再灌注模型中，超顺磁性氧化铁（SH U 555A）增强磁共振成像是否能够检测出局部肝损伤。通过血管夹闭右叶0（假手术组）、30（I - 30）、60（I - 60）和90分钟（I - 90）诱导缺血性肝损伤。在假手术组、I - 30和I - 60组中，缺血叶和非缺血叶之间的相对增强（RE）无显著差异，而在SH U 555A增强质子密度自旋回波图像上，I - 90组中缺血叶的RE显著低于其非缺血对应叶（P < 0.05）。组织学检查显示，I - 90组中缺血叶的铁沉积明显小于非缺血叶（P < 0.05），尽管库普弗细胞数量无显著差异。我们的结果表明，SH U 555A磁共振成像可评估严重的局部肝损伤。
