El-Safty S A, Shenashen M A
National Institute for Materials Science (NIMS), 1-2-1 Sengen, Tsukubashi, Ibaraki-ken, 305-0047, Japan.
Mater Today Bio. 2020 Feb 14;5:100044. doi: 10.1016/j.mtbio.2020.100044. eCollection 2020 Jan.
Early detection and easy continuous monitoring of emerging or re-emerging infectious, contagious or other diseases are of particular interest for controlling healthcare advances and developing effective medical treatments to reduce the high global cost burden of diseases in the backdrop of lack of awareness regarding advancing diseases. Under an ever-increasing demand for biosensor design reliability for early stage recognition of infectious agents or contagious diseases and potential proteins, nanoscale manufacturing designs had developed effective nanodynamic sensing assays and compact wearable devices. Dynamic developments of biosensor technology are also vital to detect and monitor advanced diseases, such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), diabetes, cancers, liver diseases, cardiovascular diseases (CVDs), tuberculosis, and central nervous system (CNS) disorders. In particular, nanoscale biosensor designs have indispensable contribution to improvement of health concerns by early detection of disease, monitoring ecological and therapeutic agents, and maintaining high safety level in food and cosmetics. This review reports an overview of biosensor designs and their feasibility for early investigation, detection, and quantitative determination of many advanced diseases. Biosensor strategies are highlighted to demonstrate the influence of nanocompact and lightweight designs on accurate analyses and inexpensive sensing assays. To date, the effective and foremost developments in various nanodynamic designs associated with simple analytical facilities and procedures remain challenging. Given the wide evolution of biosensor market requirements and the growing demand in the creation of early stage and real-time monitoring assays, precise output signals, and easy-to-wear and self-regulating analyses of diseases, innovations in biosensor designs based on novel fabrication of nanostructured platforms with active surface functionalities would produce remarkable biosensor devices. This review offers evidence for researchers and inventors to focus on biosensor challenge and improve fabrication of nanobiosensors to revolutionize consumer and healthcare markets.
在对疾病进展缺乏认识的背景下，早期发现并轻松持续监测新出现或再次出现的传染病、传染性疾病或其他疾病，对于控制医疗保健进展以及开发有效的医学治疗方法以减轻全球高昂的疾病成本负担尤为重要。在对用于早期识别传染原或传染性疾病及潜在蛋白质的生物传感器设计可靠性的需求不断增加的情况下，纳米级制造设计已开发出有效的纳米动力学传感检测方法和紧凑型可穿戴设备。生物传感器技术的动态发展对于检测和监测晚期疾病也至关重要，如人类免疫缺陷病毒（HIV）、乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）、糖尿病、癌症、肝脏疾病、心血管疾病（CVD）、结核病和中枢神经系统（CNS）疾病。特别是，纳米级生物传感器设计通过早期疾病检测、监测生态和治疗剂以及维持食品和化妆品的高安全水平，对改善健康问题做出了不可或缺的贡献。本综述报告了生物传感器设计及其对多种晚期疾病进行早期研究、检测和定量测定的可行性概述。重点介绍了生物传感器策略，以展示纳米紧凑和轻量化设计对准确分析和低成本传感检测的影响。迄今为止，与简单分析设备和程序相关的各种纳米动力学设计中的有效且首要进展仍然具有挑战性。鉴于生物传感器市场需求的广泛演变以及对创建早期和实时监测检测方法、精确输出信号以及易于穿戴和自我调节的疾病分析的需求不断增长，基于具有活性表面功能的纳米结构平台的新型制造的生物传感器设计创新将产生卓越的生物传感器设备。本综述为研究人员和发明家提供了证据，以关注生物传感器挑战并改进纳米生物传感器的制造，从而彻底改变消费和医疗保健市场。
