Kido K, Suzuki S, Amemiya H, Nakano H
First Department of Surgery, Nara Medical University, Kashihara, Japan.
Transpl Int. 1994;7 Suppl 1:S194-8. doi: 10.1111/j.1432-2277.1994.tb01345.x.
Therapeutic effect of 15-deoxyspergualin (DSG) on acute rejection was investigated by examining hepatic functions and histological findings in a model of canine liver transplantation. When acute rejection (defined as an acute rise of hepatic functions) occurred, the recipients were treated with DSG alone or combined with a small amount of methylprednisolone (MP). The recipients in group 1 were administered no basic immunosuppressant, and those in groups 2 and 3 received cyclosporine as the basic drug. The rejections in groups 1 and 2 were treated with DSG combined with MP and those in group 3, with DSG alone. Amelioration or healing of hepatic dysfunction and histological abnormalities as seen in all groups except for one case in group 3. The observations in this study were quite similar to those in renal transplantation. Therefore, DSG therapy is expected to be useful for treating graft rejection even in clinical liver transplantation.
通过检测犬肝移植模型的肝功能和组织学结果，研究了15-去氧精胍菌素（DSG）对急性排斥反应的治疗效果。当发生急性排斥反应（定义为肝功能急性升高）时，受体单独接受DSG治疗或联合少量甲泼尼龙（MP）治疗。第1组受体未给予基础免疫抑制剂，第2组和第3组受体接受环孢素作为基础药物。第1组和第2组的排斥反应采用DSG联合MP治疗，第3组的排斥反应单独采用DSG治疗。除第3组1例病例外，所有组的肝功能障碍和组织学异常均得到改善或愈合。本研究的观察结果与肾移植的观察结果非常相似。因此，即使在临床肝移植中，DSG治疗也有望用于治疗移植物排斥反应。
